乳腺癌是女性最常见的恶性肿瘤之一。肿瘤的发生、发展是多种基因共同作用的结果。与常染色体上的抑癌基因相比,X染色体连锁的抑癌基因更容易因甲基化或突变等而失活。核糖体S6蛋白激酶4(ribosomal protein S6 kinase4,RSK4)作为一个X染色体连锁基因,可抑制细胞的生长、增殖和分化。RSK4过表达可使细胞增殖下降,使停滞在G_0～G_1期的细胞增加。RSK4可能是乳腺癌的一个与X染色体连锁的抑癌基因。 Breast cancer is one of the most common malignancies in women. Tumor development, development is the result of a variety of genes together. Compared with autosomal tumor suppressor genes, X chromosome-linked tumor suppressor genes are more likely to be inactivated by methylation or mutation. Ribosomal protein S6 kinase4 (RSK4) as an X-linked gene can inhibit cell growth, proliferation and differentiation. Overexpression of RSK4 decreased cell proliferation and increased the number of cells arrested in G_0 ~ G_1 phase. RSK4 may be a tumor suppressor gene linked to the X chromosome in breast cancer.