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目的:探讨上皮钙黏蛋白和β-连环素在喉癌组织中的表达及其临床意义。方法:应用免疫组织化学PicTureTM二步法,检测上皮钙黏蛋白和β-连环素在喉癌组织和癌周正常喉组织中的表达。结果:60例喉癌患者中,上皮钙黏蛋白和β-连环素的异常表达率为55.00%(33/60)和66.67%(40/60),按喉癌的临床分期、颈部淋巴结转移情况分组比较,均差异有统计学意义(均P<0.05),喉癌的组织学分级比较,差异有统计学意义(P<0.01),喉癌的原发部位及患者的性别、年龄差异无统计学意义(P>0.05)。同一标本中上皮钙黏蛋白和β-连环素表达有显著的相关性和一致性(P<0.01)。结论:上皮钙黏蛋白和β-连环素的异常表达与喉癌分化、分期、转移密切相关。
Objective: To investigate the expression of E-cadherin and β-catenin in laryngeal carcinoma and its clinical significance. Methods: The expression of E-cadherin and β-catenin in laryngeal carcinoma and normal laryngeal tissues was detected by immunohistochemistry PicTureTM two-step method. Results: The abnormal expression rates of E-cadherin and β-catenin in 60 cases of laryngeal carcinoma were 55.00% (33/60) and 66.67% (40/60), respectively. According to the clinical stage of laryngeal cancer, cervical lymph node metastasis (P <0.05). The histological grade of laryngeal carcinoma was significantly different (P <0.01). There was no significant difference in the primary site of laryngeal carcinoma and the gender and age of the patients Statistical significance (P> 0.05). There was a significant correlation and agreement between the expression of E-cadherin and β-catenin in the same specimen (P <0.01). Conclusion: The abnormal expression of E-cadherin and β-catenin is closely related to the differentiation, staging and metastasis of laryngeal carcinoma.