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目的分析妊娠中期进行产前诊断的高危孕妇羊水细胞染色体核型,了解此期异常核型出现的频率及类型。方法 6887例具备产前诊断指征的妊娠妇女,在知情选择的情况下行羊膜腔穿刺术及染色体核型检测。结果 6876例羊水细胞培养成功,成功率为99.84%(6876/6887)。在6876例羊水细胞培养成功的染色体核型中,检出异常核型107例,异常率为1.56%,常见核型为三体型,占异常核型47.66%。结论羊水细胞学检查作为一项产前诊断技术对于指导优生优育,降低缺陷儿的出生具有重要意义。
Objective To analyze the chromosomal karyotypes of amniotic fluid cells in high-risk pregnant women who have been diagnosed in prenatal period and find out the frequency and types of abnormal karyotypes in this period. Methods 6887 pregnant women with prenatal diagnosis indications underwent amniocentesis and chromosomal karyotyping with informed choice. Results 6876 cases of amniotic fluid cells were successfully cultured with a success rate of 99.84% (6876/6887). In 6876 cases of amniotic fluid cell culture successful karyotypes, 107 cases of abnormal karyotype detected, the abnormal rate was 1.56%, common karyotype trisomy, accounting for 47.66% of abnormal karyotype. Conclusions Amniotic fluid cytology is an important prenatal diagnosis technique for guiding prenatal and postnatal care and reducing birth defects.