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异种移植目前需要解决的主要问题仍是超急排斥反应。异种移植物血管内皮细胞上的异种抗原是导致超急排斥反应发生的关键。本文从异种抗原的性质、遗传学特征、分布和作用等方面介绍了近年来在异种移植领域中的研究现状及有可能消除异种抗原的分子生物学技术。
The main problem that needs to be solved at present is the hyperacute rejection. Heterologous antigens on xenograft vascular endothelial cells are the key to the occurrence of hyperacute rejection. In this paper, the current research status in xenotransplantation in recent years and the molecular biology techniques that may eliminate xenoantigens are introduced from the aspects of the properties, genetics, distribution and function of xenoantigens.