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目的观察肝动脉介入治疗后碘油沉积欠佳者,镇痛泵持续灌注化疗治疗肝癌疗效。方法seldinger技术腹腔干造影后选择置入肝动脉,碘油沉积欠佳和少血供者予顺氯胺铂(DDP)60mg,5-氟脲嘧啶(5-FU)0.75g,阿霉素(ADM)50mg灌注化疗后,5-FU0.75g自控镇痛泵持续肝动脉灌注化疗12h。结果临床受益率差异无统计学意义(P>0.05)。恶心呕吐、白细胞毒性反应差异无统计学意义(P>0.05),胆红素、转氨酶等毒性反应明显,差异有统计学意义(P<0.05)。但胆红素毒性反应Ⅱ度以内,且4周内恢复,但患者生存时间延长2个月。结论临床经济安全,生存时间有所延长,值得临床推广。
Objective To observe the poor deposition of lipiodol after interventional treatment of hepatic artery and the effect of continuous infusion chemotherapy of analgesia pump on liver cancer. Methods seldinger technique after celiac angiography selected into the hepatic artery, poor lipiodol deposition and less blood donor to cisplatin (DDP) 60mg, 5-fluorouracil (5-FU) 0.75g, doxorubicin ADM) 50mg infusion chemotherapy, 5-FU0.75g controlled analgesia pump continuous hepatic artery infusion chemotherapy for 12h. Results The clinical benefit rate difference was not statistically significant (P> 0.05). Nausea and vomiting, no significant difference in leukocyte toxicity (P> 0.05), bilirubin, aminotransferase and other toxic reactions were significantly different (P <0.05). However, bilirubin toxicity within the second degree and recovery within 4 weeks, but patients with prolonged survival of 2 months. Conclusion Clinical economic security, survival time has been extended, it is worth clinical promotion.