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一氧化氮（ＮＯ）在活化巨噬细胞抗某些肿瘤细胞和微生物上起重要作用。用不同剂量的母牛分支杆菌制剂免疫ＢＡＬＢ／ｃ小鼠，检测小鼠腹腔巨噬细胞产生一氧化氮的水平，结果显示受免疫小鼠腹腔巨噬细胞产生一氧化氮水平明显高于未免疫小鼠（Ｐ＜０．０１－０．００１）。不同剂量母牛分支杆菌制剂免疫的ＢＡＬＢ／ｃ小鼠，腹腔巨噬细胞产生的一氧化氮水平差别不显著（Ｐ＞０．０５）。因此认为，母牛分支杆菌制剂作为结核病免疫治疗剂其作用之一是活化巨噬细胞产生一氧化氮，从而达到杀菌的目的。
Nitric oxide (NO) plays an important role in activating macrophages against certain tumor cells and microorganisms. BALB / c mice were immunized with different doses of Mycobacterium vaccae preparations to detect the levels of nitric oxide produced by peritoneal macrophages. The results showed that the level of nitric oxide produced by peritoneal macrophages of immunized mice was significantly higher than that of non-immunized mice Mice (P <0.01-0.001). The levels of nitric oxide produced by peritoneal macrophages in BALB / c mice immunized with different doses of Mycobacterium vaccae were not significantly different (P> 0.05). So that the mycobacterium preparation as a tuberculosis immunotherapy, one of its role is to activate macrophages to produce nitric oxide, so as to achieve the purpose of sterilization.