癫痫与心血管疾病(cardiovascular disease,CVD)互为因果,癫痫可增加CVD的发生率和死亡率,而CVD可诱发癫痫猝死。不同的抗癫痫药物对CVD危险因素的影响各异,这些危险因素包括体质量、胰岛素抵抗、代谢综合征、血清尿酸水平、颈动脉内膜中层厚度和氧化应激标志物等。鉴于部分抗癫痫药物可能增加或降低CVD发生风险,因此在实施个体化的抗癫痫治疗时,对于有较高CVD发生风险的癫痫患者应选择合适的抗癫痫药物,同时合理使用可降低CVD发生风险的药物。 Epilepsy and cardiovascular disease (cardiovascular disease) each other cause and effect, epilepsy can increase the incidence of CVD and mortality, and CVD can induce sudden death in epilepsy. Different anti-epileptic drugs have different effects on CVD risk factors, including body mass, insulin resistance, metabolic syndrome, serum uric acid levels, carotid artery intima-media thickness and oxidative stress markers. As some antiepileptic drugs may increase or decrease the risk of CVD, proper antiepileptic drugs should be selected in patients with epilepsy at higher risk of CVD when implementing personalized antiepileptic therapy, and reasonable use can reduce the risk of CVD Drug.