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平阳霉素是一种抗肿瘤抗生素，它可以和ＤＮＡ发生嵌合效应并伴有ＤＮＡ的断链。实验表明，在Ｆｅ（ＩＩ）存在下，平阳霉素对质粒ＤＮＡ和几ＤＮＡ均产生非特异性断链作用，还原剂二硫苏糖醇（ＤＴＴ）对这种断链起促进作用，螯合剂ＥＤＴＡ则起抑制作用。平阳霉素与小牛胸腺ＤＮＡ作用后，在２６０ｎｍ处吸收峰随平阳霉素浓度的增加而加强，而ＣＤ谱负带振幅明显变小，表明ＤＮＡ分子构象发生了明显变化。
Pingyangmycin is an antitumor antibiotic, it can chimeric with DNA and accompanied by DNA chain scission. Experiments show that in the presence of Fe (II), Pingyangmycin on plasmid DNA and several DNA have a non-specific chain scission, reducing agent dithiothreitol (DTT) on this chain scission play a catalytic role of chelator EDTA It plays a suppressive role. After the interaction of pingyangmycin and calf thymus DNA, the absorption peak at 260nm intensified with the increase of pingyangmycin concentration, while the amplitude of minus band of CD spectrum was obviously smaller, indicating that the conformation of DNA molecules changed obviously.