FoxM1是Fox转录因子家族中的一员,特异性表达于增殖期细胞中,在细胞分化终末时消失。FoxM1与细胞生长关系密切,主要通过抑制细胞周期素依赖性激酶抑制剂介导细胞增殖,还参与生长激素介导的细胞增殖。目前研究表明,FoxM1在多种恶性肿瘤细胞中高表达,与肿瘤的发生、发展密切相关,可能是多种肿瘤细胞增殖所必需的一种原癌基因。本文就FoxM1与肿瘤关系相关研究进展作一综述。 FoxM1, a member of Fox family of transcription factors, is specifically expressed in proliferating cells and disappears at the end of cell differentiation. FoxM1 is closely related to cell growth and mediates cell proliferation mainly through the inhibition of cyclin-dependent kinase inhibitors and is also involved in growth hormone-mediated cell proliferation. The current research shows that FoxM1 is highly expressed in many malignant tumor cells and is closely related to the occurrence and development of tumors, and may be a protooncogene necessary for the proliferation of various tumor cells. This article reviews the related research progress of FoxM1 and tumor.