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目的 探讨雷公藤多甙辅助治疗紫癜性肾炎的临床意义。方法 5 0例患儿随机分为对照组 2 1例 ,治疗组 2 9例。对照组仅给激素、抗过敏药物治疗 ;治疗组除给予激素、抗过敏药物外加雷公藤多甙 ,比较两组的治疗疗效及随访 1年后的复发率。结果 两组尿蛋白定量均显著降低 ,而治疗组蛋白尿水平低于对照组 ;随访 1年治疗组复发率为 3 4 6%;对照组为 47 2 %且P <0 0 1,两组间的差异十分显著。结论 雷公藤多甙辅助治疗紫癜型肾炎可以有效提高患者的缓解率、降低其复发率及对预后有积极作用
Objective To investigate the clinical significance of tripterygium glycosides in the treatment of purpuric nephritis. Methods Fifty cases of children were randomly divided into control group 21 cases, treatment group 29 cases. The control group was treated with hormone and antiallergic drugs only. The treatment group was given hormones and antiallergic drugs plus tripterygium glycosides, and the curative effect and recurrence rate after one year follow-up were compared. Results The proteinuria of both groups was significantly decreased, while the level of proteinuria in the treatment group was lower than that of the control group. The recurrence rate was 34.6% in the one-year follow-up group and 47.2% in the control group (P <0.01) The difference is very significant. Conclusion Tripterygium glycosides adjuvant treatment of purpura nephritis can effectively improve the patient’s remission rate, reduce the recurrence rate and have a positive effect on prognosis