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抗日本血吸虫生殖及卵胚发育免疫的研究是血吸虫疫苗研究的重要策略之一．本研究探讨了未成熟卵等不同抗原免疫诱导宿主产生抗日本血吸虫生殖及卵胚发育免疫的效果．研究证明SIEA26－28kDa抗原能诱导小鼠产生抑制雌虫生殖和卵胚发育成熟的免疫力．与对照组比较，SIEA26－28kDa抗原免疫鼠减虫虽不明显，但肝组织内每雌产卵数、成熟卵数和粪卵数（EPG）分别减少48．1％、83．6％、87．3％，死亡卵数明显增加（t=3．91，P＜0.01）．此外，未纯化的SIEA和纯化的SIEA26－28kDa、Sj31／32kDa抗原免疫组约见雌虫子宫内虫卵数下降，分别达40．9％、54．8％、53．2％，而成熟虫卵可溶性抗原（SEA）和SIEA－TGP抗原免疫未见上述故应．采用未成熟抗原或Sj31／32kDa、SIEA26－28kDa等三联抗原，分别对大动物（牲猪）进行免疫．与对照组比较，免疫猪肝脏表面虫卵结节的数量显著下降（86．5％），组织中虫卵数、粪卵数分别下降78.0％和90.6％．
Anti-Schistosoma japonicum reproduction and oocyte developmental immunity research is one of the important strategies for schistosome vaccine research. This study explored the immature egg and other antigens induced by different antigens induced host anti-Schistosoma japonicum reproductive and oocyte developmental immunity effect. Studies have shown that SIEA26-28kDa antigen can induce mice to produce the female reproductive and oocyte maturation immunity. Compared with the control group, SIEA26-28kDa antigen immunized mice were not significantly reduced, but the number of eggs per female, the number of mature eggs and the number of excreted eggs (EPG) decreased by 48.1%, 83.6%, 87 .3%, the number of eggs died significantly increased (t = 3.91, P <0.01). In addition, the un-purified SIEA and purified SIEA26-28kDa, Sj31 / 32kDa antigen immunohistochemistry, see the female intrauterine insects reduced the number of eggs, respectively, 40.9%, 54.8%, 53.2%, while mature eggs Immune response to soluble antigen (SEA) and SIEA-TGP antigen is not seen above. Using immature antigen or Sj31 / 32kDa, SIEA26-28kDa triple antigen, respectively, for large animals (pigs) immunization. Compared with the control group, the number of egg nodules on the surface of immunized pigs decreased significantly (86.5%), and the numbers of eggs and fecal eggs in the tissues decreased by 78.0% and 90.6%, respectively.