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SP是外周向中枢传递伤害性信息的重要神经活性物质，而FOS蛋白可作为脊髓和延髓神经元被伤害性刺激信息激活的标志。鞘内注射一定浓度和剂量的SP可激活脊髓背角神经元的S－fos基因并表达FOS；而鞘内注射SP受体桔抗剂则可抑制此表达。但SP在外周通过何种结构影响伤害性刺激信息?
SP is an important neuroactive substance that transmits nociceptive information to the peripheral center, whereas FOS protein can serve as a marker of activation of nociceptive information in spinal cord and medulla oblongata. Intrathecal injection of certain concentrations and doses of SP can activate the S-fos gene of spinal dorsal horn neurons and express FOS; and intrathecal injection of SP receptor antagonist can inhibit this expression. However, the structure of SP in the periphery through the impact of nociceptive information?