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目的观察乌司他丁治疗慢性阻塞性肺疾病急性加重期(AECOPD)合并全身炎症反应综合征(SIRS)患者的临床疗效。方法将64例AECOPD合并SIRS患者随机分成两组:对照组仅用常规治疗,治疗组另加乌司他丁60万U静脉滴注,每日2次。观察两组1周后治疗效果、动脉血气分析及肺功能改善情况。结果治疗组疗效优于对照组,动脉血气及肺功能改善情况也优于对照组(P<0.05)。结论乌司他丁能明显改善AECOPD并SIRS患者动脉血气及肺功能,提高治疗效果。
Objective To observe the clinical efficacy of ulinastatin in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated with systemic inflammatory response syndrome (SIRS). Methods Sixty-four AECOPD patients with SIRS were randomly divided into two groups: the control group received only routine treatment, the treatment group plus ulinastatin 600,000 U intravenous infusion twice daily. One week after treatment, the therapeutic effect, arterial blood gas analysis and pulmonary function improvement were observed. Results The curative effect of the treatment group was better than that of the control group. The improvement of arterial blood gas and pulmonary function was also better than that of the control group (P <0.05). Conclusion Ulinastatin can significantly improve arterial blood gas and lung function in patients with AECOPD and SIRS, and improve the therapeutic effect.