急性呼吸窘迫综合征 (ARDS)是ICU患者高病死率的主要原因 ,文献对该病起始和预后的预测因素报道较少。最近研究发现人类血管紧张素转换酶 (ACE)基因含有多态性 ,其插入 /缺失 (I/D)状态能增强 /减弱血浆和组织中的ACE活性。在ARDS中不但D等位基因频率高 ,DD -ACE基因型频率亦高 Acute respiratory distress syndrome (ARDS) is the main cause of high mortality in patients with ICU, the literature on the onset and prognosis of the prognostic factors reported less. Recent studies have found that human angiotensin-converting enzyme (ACE) genes contain polymorphisms whose insertion / deletion (I / D) status enhances / diminishes ACE activity in plasma and tissue. In ARDS not only D allele frequency is high, DD -ACE genotype frequency is also high