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目的:探讨戊酸雌二醇联合米非司酮应用于绝经期宫内节育器(IUD)取出的效果。方法:将行IUD取出术的绝经后妇女180例随机分成3组,A组:术前服用戊酸雌二醇;B组:术前服用戊酸雌二醇+米非司酮;C组:术前不用任何药物;比较3组间宫颈扩张程度、术中出血量、术后腹痛程度、手术难易程度及成功率。结果:A组与B组在宫颈扩张无效例数、手术困难程度方面有显著性差异(P<0.05);A组与B组在术中出血量、术中、术后腹痛程度及成功率方面均无显著性差异(P>0.05)。而A组、B组分别与C组比较,以上各项指标均有显著性差异(P<0.05)。结论:戊酸雌二醇联合米非司酮用于取出绝经期IUD,可以软化宫颈,改善手术条件,降低手术难度,减轻患者的痛苦,提高取器成功率,值得临床推广。
Objective: To investigate the effect of estradiol valerate combined with mifepristone in the treatment of menopause IUD. Methods: One hundred and eighty postmenopausal women who underwent IUD removal were randomly divided into three groups: group A: estradiol valerate preoperatively; group B: estradiol valerate and mifepristone before operation; group C: Before surgery without any drugs; compare the degree of cervical dilation between the three groups, intraoperative blood loss, postoperative abdominal pain, degree of difficulty and success rate of surgery. Results: In group A and group B, there were significant differences in the number of ineffective cervical dilatation and the degree of surgical difficulty (P <0.05). In group A and group B, the intraoperative blood loss, degree of intraoperative and postoperative abdominal pain and success rate No significant difference (P> 0.05). The A, B group and C group, the above indicators were significantly different (P <0.05). Conclusion: The combination of estradiol valerate and mifepristone for removing IUD during menopause can soften the cervix, improve the surgical conditions, reduce the difficulty of operation, alleviate the suffering of patients and improve the success rate of the device. It is worthy of clinical promotion.