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目的 通过对窒息新生儿表皮生长因子（Epidermal growth factor,EGF）、神经降压素（Neurotensin,NT）、生长抑素（Somatostatin,SS）的水平监测,EGF、NT、SS水平与临床因素关系的研究,探讨围产期窒息对消化道激素的影响。方法:采用放射免疫方法,动态测定了56例窒息新生儿和39例正常足月儿生后1、3、7天血中EGF、NT、SS水平的变化。结果与正常对照组比较:窒息新生儿血中NT、SS水平明显升高,EGF水平明显降低,差异显著,P<0.05;生后第7天窒息组EGF、SS水平恢复正常,但NT水平则仍较相应正常对照组升高（116.4,118.2vs 84.7ng/L）,P<0.01;与临床因素相关分析显示:EGF与1分钟Apgar评分呈正相关,r=0.3149,P<0.01;NT与1分钟Apgar评分呈负相关,r=-0.368,P<0.001;NT、EGF分别与胎龄、奶量呈正相关,P<0.01;SS与空腹血糖（FBS）呈正相关,r=0.222,P<0.05。结论 窒息后新生儿血中NT、SS浓度升高,EGF浓度降低,且与窒息程度有关。表明窒息新生儿胃肠激素水平异常,可能是造成患儿消化功能紊乱的因素之一。
Objective To investigate the relationship between the level of EGF, NT, SS and clinical factors by monitoring the levels of epidermal growth factor (EGF), neurotensin (NT) and somatostatin (SS) To study and explore the effects of perinatal asphyxia on gastrointestinal hormones. Methods: The levels of EGF, NT and SS in blood of 56 neonates with asphyxia and 39 normal term neonates were measured by radioimmunoassay. Results Compared with the normal control group, NT and SS levels and EGF levels in neonatal asphyxia neonates were significantly lower than those in normal control group (P <0.05), while levels of EGF and SS in asphyxia group returned to normal on the 7th day after birth (116.4,118.2 vs 84.7ng / L), P <0.01. Correlation with clinical factors showed that there was a positive correlation between EGF and Apgar score at 1 minute (r = 0.3149, P <0.01) (P <0.001). There was a positive correlation between NT and EGF and gestational age and milk volume (P <0.01), SS and FBS (r = 0.222, P <0.05) . Conclusion Asphyxial neonatal blood NT, SS concentration increased, EGF concentration decreased, and the degree of asphyxia. Asphyxia neonatal gastrointestinal hormone abnormalities that may be one of the factors that cause digestive disorders in children.