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目的探讨血胰岛素样生长因子I(IGFI)与早产儿早期营养、生长调控的关系。方法采用酶联免疫法测定41例早产适于胎龄儿出生后第8、15天的血清IGFI质量浓度。同时监测早产儿的体重、Kaup指数以及每天实际摄入的能量、蛋白质和母乳量。结果早产儿出生后第8天血清IGFI质量浓度与胎龄、出生体重以及出生后3～7d实际摄入的能量、蛋白质的量呈正相关(P<0.05)。第15天血清IGFI质量浓度与出生后8～14d实际摄入的能量、蛋白质的量呈正相关(P<0.05),而与胎龄、出生体重不相关(P>0.05)。早产儿在出生体重、胎龄、摄入的蛋白质和能量的量同等的情况下,摄入母乳量对血清IGFI质量浓度有正性影响(P<0.05)。血清IGFI质量浓度随着早产儿的日龄而上升,与体重增长速度和Kaup指数呈正相关(P<0.05)。结论血清IGFI质量浓度受到早产儿摄入能量、蛋白质、母乳量和日龄的影响,是早产儿生后早期的生长调控激素,IGFI可作为反映早产儿早期营养和生长的一个指标。
Objective To investigate the relationship between insulin-like growth factor I (IGFI) and early nutrition and growth regulation of premature infants. Methods The serum IGFI concentrations of 41 premature infants born at 8th and 15th days after birth were measured by enzyme-linked immunosorbent assay. Body weight, Kaup index, and actual daily intake of energy, protein and breast milk were also monitored. Results The serum IGFI concentration on the 8th day after birth in preterm infants was positively correlated with the actual intake of energy and protein at 3 ~ 7 days after birth (P <0.05). The serum IGFI concentration on day 15 was positively correlated with the amount of energy and protein actually consumed at 8-14 days after birth (P <0.05), but not with gestational age and birth weight (P> 0.05). Preterm infants had a positive effect on the serum IGFI concentration (P <0.05) with the same birth weight, gestational age, intake of protein and energy. Serum IGFI concentration increased with the age of premature infants and positively correlated with the rate of weight gain and Kaup index (P <0.05). Conclusion Serum IGF1 concentration is influenced by the energy intake, protein, milk yield and age of preterm infants. It is an early growth hormone in preterm infants. IGFI can be used as an indicator of early nutrition and growth of premature infants.