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目的 :了解肝硬化患者的肺功能状态。方法 :测定 40例肝硬化患者的肺功能及血气分析 ,并以健康人群作对照。结果 :肝硬化患者肺功能指标 (FVC、FEV1、FEV1/FVC、MVV、V2 5、V50 、V75、DLCO、PaO2 )较健康对照组明显减低 ,P(A a)O2 明显升高 ,有显著差异 (P <0 0 1)。且肝硬化患者病情越严重肺功能损害越明显。结论 :肝硬化患者的FVC、FEV1、FEV1/FVC、MVV、V2 5、V50 、V75、DLCO、PaO2 较对照组明显降低 ,P(A a)O2 明显升高 ,表明肝硬化患者存在肺通气功能障碍和弥散功能障碍。腹水、肝性胸水是肺通气功能障碍的主要原因 ;而肺内血流异常 (肺内动 静脉分流和肺血管扩张 )是肺弥散功能障碍的主要原因。
Objective: To understand the pulmonary function of patients with cirrhosis. Methods: The pulmonary function and blood gas analysis of 40 patients with cirrhosis were measured and compared with healthy people. Results: The pulmonary function indexes (FVC, FEV1, FEV1 / FVC, MVV, V2 5, V50, V75, Dlco and PaO2) in cirrhotic patients were significantly lower than those in healthy controls (P <0 0 1). And the more serious the condition of patients with liver cirrhosis, the more obvious damage to lung function. Conclusions: The FVC, FEV1, FEV1 / FVC, MVV, V2 5, V50, V75, DLCO and PaO2 in patients with cirrhosis were significantly lower than those in the control group and P (Aa) O2 was significantly increased, indicating the presence of pulmonary ventilation Disorders and diffuse dysfunction. Ascites and hepatic pleural effusion are the main causes of pulmonary dysfunction; and abnormal pulmonary blood flow (pulmonary arteriovenous shunt and pulmonary vasodilation) is the main cause of pulmonary diffuse dysfunction.