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目的探讨在甲真菌病合并糖尿病情况下,血中白细胞介素-1β(IL-1β)、IL-6和肿瘤坏死因子α(TNF-α)含量变化及真菌菌种分布情况。方法采用酶联免疫测定方法 ,对53例甲真菌病患者、51例甲真菌病合并糖尿病患者、49例糖尿病患者及50名健康人进行血IL-1β、IL-6和TNF-α含量测定,并对甲真菌病及甲真菌病合并糖尿病患者的甲真菌病常见菌种构成进行比较。结果甲真菌病组血清IL-1β、IL-6、TNF-α含量高于对照组;糖尿病甲真菌病组血中IL-6和TNFα含量明显高于甲真菌病组和糖尿病组(P<0.05);糖尿合并甲真菌病组中,病原菌仍以皮肤癣菌为主,甲真菌病组酵母菌高于对照组。结论 IL-1β、IL-6及TNF-α是糖尿病合并甲真菌感染中的一类重要的炎性反应介质,在甲真菌病的发生、发展过程中可能起重要作用。
Objective To investigate the changes of blood levels of interleukin-1β (IL-1β), IL-6 and tumor necrosis factor-α (TNF-α) and the distribution of fungal strains in the presence of onychomycosis and diabetes mellitus. Methods Serum levels of IL-1β, IL-6 and TNF-α were measured in 53 cases of onychomycosis, 51 cases of onychomycosis with diabetes mellitus, 49 cases of diabetes mellitus and 50 healthy persons by enzyme-linked immunosorbent assay. The comparison of common bacterial species of onychomycosis onychomycosis and onychomycosis with diabetic mellitus was conducted. Results The levels of serum IL-1β, IL-6 and TNF-α in the group with onychomycosis were higher than those in the control group. The levels of IL-6 and TNFα in the group with onychomycosis were significantly higher than those in the group with onychomycosis and diabetes (P <0.05 ). In diabetic group with onychomycosis, the pathogen was still predominantly dermatophyte, but the yeasts in onychomycosis group were higher than those in control group. Conclusion IL-1β, IL-6 and TNF-α are an important inflammatory mediators in the treatment of onychomycosis in diabetic patients, which may play an important role in the occurrence and development of onychomycosis.