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观察卡托普利、地高辛及联合用药治疗46例心衰患者和11例洋地黄中毒患者红细胞内钠(Na~+i)钾(K~+i)和血浆地高辛浓度。结果:卡托普利组和联合组Na~+i(x±s)为10.67±1.31和11.63±0.99mmol/L,K~+i为93.15±5.07和91.55±3.16mmol/L,与地高辛组Na~+i 12.97±0.84mmol/L、K~+i 88.80±2.32mmol/L,洋地黄中毒组Na~+i 15.63±1.97mmol/L、K~+i81.74±2.89mmol/L比较,差异有显著性意义(P<0.05或<0.01)。联合组血浆地高辛浓度比地高辛组增高。示卡托普利可避免Na~+i高、K~+i低,故可能降低洋地黄中毒发生率。与小剂量地高辛合用可达较高血浆地高辛浓度,利于慢性心衰的治疗。
To observe the concentration of sodium (Na ~ + i) potassium (K ~ + i) and plasma digoxin in 46 patients with heart failure and 11 digitalis poisoning patients treated with captopril, digoxin and combination therapy. Results: In the captopril group and the combination group, Na ~ + i (x ± s) was 10.67 ± 1.31 and 11.63 ± 0.99mmol / L, K ~ + i was 93.15 ± 5.07 and 91.55 ± 3.16mmol / L, In Xinxin group, Na ~ + i 12.97 ± 0.84mmol / L, K ~ + i 88.80 ± 2.32mmol / L, and digitalis poisoning group Na ~ + i 15.63 ± 1.97mmol / L and K ~ + i 81.74 ± 2.89mmol / L The difference was significant (P <0.05 or <0.01). Plasma digoxin concentrations in the combined group were higher than those in the digoxin group. Captopril can avoid Na ~ + i high, K ~ + i low, it may reduce the incidence of digitalis poisoning. Combined with low doses of digoxin can reach a higher concentration of plasma digoxin, which is conducive to the treatment of chronic heart failure.