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目的探讨早老素相关菱形样蛋白(PARL)基因Leu262Val多态性与2型糖尿病(T2DM)及糖尿病肾病(DN)的相关性。方法运用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,在昆明地区汉族人中对278例T2DM患者[其中正常白蛋白尿(DN0)组102例,微量白蛋白尿(DN1)组91例,临床白蛋白尿(DN2)组85例]和113例健康对照者(NC)的PARL基因Leu262Val多态性进行检测,并比较分析各组间基因型频率和等位基因频率以及相关临床资料。结果 T2DM组和NC组间,DN组(DN1+DN2)、DN0组和NC组各组间基因型频率及等位基因频率差异均无统计学意义(P>0.05),二分类Logistic回归分析表明:在T2DM患者中,DM病程、收缩压(SBP)、甘油三酯(TG)和糖化血红蛋白百分比(HbA1c%)是DN发生的危险因素。结论在昆明地区汉族人中PARL基因Leu262Val多态性可能与T2DM及DN的发生无相关性;DM病程、SBP、TG、HbA1c可能是DN的危险因素。
Objective To investigate the association between polymorphism of Leu262Val polymorphism of PARL gene and type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN). Methods A total of 278 T2DM patients (including 102 cases of normal albuminuria (DN0) group, microalbuminuria 91 cases of DN1), 85 cases of clinical albuminuria (DN2) and 113 cases of healthy controls (NC). The genotype frequency and allele frequency of each group were compared And related clinical data. Results There were no significant differences in genotype frequency and allele frequencies between DN group (DN1 + DN2), DN0 group and NC group (P> 0.05) between T2DM group and NC group. Logistic regression analysis showed that there was no significant difference : DM duration, systolic blood pressure (SBP), triglyceride (TG), and percentage of HbA1c% are risk factors for DN in T2DM patients. Conclusions The Leu262Val polymorphism of PARL gene in Kunming Han people may not be related to the occurrence of T2DM and DN. The course of DM, SBP, TG and HbA1c may be the risk factors of DN.