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目的整理我院宫颈癌患者的术后辅助放疗资料,探讨宫颈癌根治术后采用放疗±同步化疗的效果。方法选取2010-01-2011-01河北省邢台市人民医院收治的96例宫颈癌患者,将其随机分为观察组和对照组,每组各48例患者,观察组采用术后放疗+同步化疗,对照组采用术后单纯放疗,比较两组患者的治疗效果。结果观察组1年生存率为93.75%,3年生存率为70.83%,5年生存率为58.33%,对照组1年生存率为72.91%,3年生存率为47.91%,5年生存率为37.50%,观察组5年内复发率为12.50%,对照组5年内复发率为37.50%,两组患者5年生存率与5年内复发率差异有统计学意义,P<0.05。观察组恶心呕吐发生率62.50%,急性放射性肠炎发生率为64.58%,膀胱炎发生率为20.83%,骨髓抑制发生率为81.25%;对照组恶心呕吐发生率为12.50%,急性放射性肠炎发生率为37.50%,膀胱炎发生率为0.83%,骨髓抑制发生率为33.33%,两组不良反应发生率差异有统计学意义,P<0.05。结论宫颈癌根治术后辅助放疗+同步化疗的临床治疗效果好,5年后复发率更低,生存率更高,但较术后单纯放疗具有更高的不良反应发生率,值得临床注意。宫颈癌根治术后辅助放疗+同步化疗治疗效果更加明显,不良反应尚能耐受,值得临床推广应用。
Objective To organize the data of postoperative adjuvant radiotherapy in patients with cervical cancer in our hospital and discuss the effect of ± synchronous chemotherapy with radiotherapy after radical operation of cervical cancer. Methods A total of 96 patients with cervical cancer admitted to Xingtai People’s Hospital of Hebei Province from January 2010 to November 2011 were selected and randomly divided into observation group and control group with 48 patients in each group. The patients in observation group received postoperative radiotherapy plus synchronous chemotherapy , The control group with postoperative radiotherapy alone, compared the treatment effect of two groups of patients. Results The 1-year survival rate of the observation group was 93.75%, the 3-year survival rate was 70.83%, the 5-year survival rate was 58.33%, the 1-year survival rate was 72.91%, the 3-year survival rate was 47.91%, and the 5-year survival rate was 37.50%. The recurrence rate in the observation group was 12.50% within 5 years, and the recurrence rate in the control group was 37.50% in 5 years. There was significant difference between 5-year survival rate and 5-year recurrence rate in the two groups (P <0.05). The incidence of nausea and vomiting in the observation group was 62.50%, the incidence of acute radiation enteritis was 64.58%, the incidence of cystitis was 20.83% and the incidence of bone marrow suppression was 81.25%. The incidence of nausea and vomiting in the control group was 12.50%. The incidence of acute radiation enteritis was 37.50%. The incidence of cystitis was 0.83%. The incidence of bone marrow suppression was 33.33%. There was a significant difference in the incidence of adverse reactions between the two groups (P <0.05). Conclusions The curative effect of adjuvant radiotherapy + synchronous chemotherapy after radical operation of cervical cancer is good. The recurrence rate is lower and the survival rate is higher after 5 years. However, it has a higher incidence of adverse reactions than radiotherapy alone, which deserves clinical attention. Cervical cancer after adjuvant radiotherapy + synchronous chemotherapy treatment effect is more obvious, the adverse reactions are still able to tolerate, worthy of clinical application.