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目的探讨先天性巨细胞病毒(HCMV)感染围生儿的预后。方法1996年1月至2004年8月,中山大学附属二院对HCMV活动性感染孕妇的23例先天感染儿及35例非感染儿,于出生时至8岁进行体格和神经系统发育的随访。1、6个月时应用聚合酶链反应(PCR)检测尿HCMVDNA。结果HCMV先天感染儿畸形、发育商(DQ)落后、听力(BAEP)异常率显著高于非先天感染儿(P<0.05)。结论先天性HCMV感染可能导致胎儿畸形,并对智力及听力有远期影响。应加强围生期管理,减少先天感染儿出生,随访感染儿并及早干预。
Objective To investigate the prognosis of children with congenital cytomegalovirus (HCMV) infection. Methods From January 1996 to August 2004, 23 cases of congenital infection and 35 non-infected children with HCMV active infection in pregnant women of Second Affiliated Hospital of Sun Yat-sen University were followed up for physical and neurological development from birth to 8 years old. Urine HCMVDNA was detected by polymerase chain reaction (PCR) at 1 month and 6 months. Results HCMV congenital infection deformity, traders (DQ) backward, abnormal hearing (BAEP) was significantly higher than non-innate infection (P <0.05). Conclusion Congenital HCMV infection may lead to fetal malformations, and have long-term effects on intelligence and hearing. Perinatal management should be strengthened to reduce birth of congenital infection, follow-up of infected children and early intervention.