survivin是近年来发现的凋亡抑制蛋白(IAP)家族的新成员,具有双重功能:既能抑制细胞凋亡,又可以调节有丝分裂。它选择性表达于常见的多种恶性肿瘤,而在正常组织和成人分化组织中并不表达,因此可作为一个潜在的药物靶向,同时又与肿瘤的发病机制、化疗及预后密切相关,有着极为广阔的应用前景。 Survivin is a new member of the apoptosis-inhibitory protein (IAP) family found in recent years. It has the dual function of inhibiting apoptosis and regulating mitosis. It is selectively expressed in a variety of common malignant tumors, but not in normal and adult differentiated tissues, and therefore can be used as a potential drug target. At the same time, it is closely related to tumor pathogenesis, chemotherapy and prognosis. Very broad application prospects.