代谢综合征(MS)是多种代谢成分异常聚集的病理状态。世界卫生组织在1999年对 MS 的定义中指出:MS 包含的主要成分有糖调节受损或糖尿病、胰岛素抵抗(IR)、高血压、高甘油三酯(TG)血症和(或)低高密度脂蛋白血症、腹部肥胖、微量白蛋白尿;次要成分有高尿酸血症、凝血功能障碍、纤溶酶原激活物抑制因子-1水平升高等。20多年来人们围绕 MS 的相关成分广泛地开展研究并不断发现新的相关成分如:瘦素、炎症因子、肿瘤坏死因子、非酒精性脂肪肝等。MS 中的多种代谢异常聚集的状态,提示这些代谢异常可能存在共同机制,通过某些代谢途径相互联系着,其中可能存在一个或多个启动因素、启动通道并导致了一系列代谢紊乱的发生。目前普遍认为胰岛素抵抗(IR),即胰岛素敏 Metabolic syndrome (MS) is a pathological condition in which various metabolic components are abnormally aggregated. According to the 1999 definition of MS by WHO, MS contains the main components of impaired glucose regulation or diabetes, insulin resistance (IR), hypertension, hypertriglyceridemia (TG) and / or low Density lipoproteinemia, abdominal obesity, microalbuminuria; secondary components of hyperuricemia, coagulation disorders, plasminogen activator inhibitor-1 levels and so on. For more than two decades, researchers have studied extensively about the related components of MS and have continuously found new relevant components such as leptin, inflammatory factors, tumor necrosis factor, non-alcoholic fatty liver. MS in the accumulation of a variety of metabolic abnormalities suggest that these metabolic abnormalities may exist a common mechanism through some metabolic pathways linked to each other, in which there may be one or more initiators, start the channel and lead to a series of metabolic disorders . It is generally accepted that insulin resistance (IR), insulin sensitivity