目的　探讨肺癌组织层粘连蛋白 (LN)及其受体 (LN -R)的表达和肿瘤转移及预后关系。方法　采用免疫组织化学技术。结果　肺癌组织细胞病理分级越高 ,LN表达程度越强 ,即病理Ⅰ级与Ⅱ级 ,Ⅲ～Ⅳ级之间有显著差异 ,且表达与有无淋巴结转移存在差异 (P <0 0 5 ) ,死亡病例中其肺癌组织LN -R表达明显增高。结论　LN及其受体 (LN -R)表达在肺癌组织的恶性生物学行为中具有重要价值 ,是临床治疗和预后估计的有用指标 Objective To investigate the relationship between the expression of laminin (LN) and its receptor (LN-R) and tumor metastasis and prognosis in lung cancer. Methods Immunohistochemical technique was used. Results The higher the pathological grade of lung cancer was, the higher the degree of LN expression was (P <0.05), that is, there was a significant difference between the pathological grade Ⅰ and grade Ⅱ, Ⅲ ~ Ⅳ and the difference between the expression and the presence or absence of lymph node metastasis The LN-R expression in lung cancer tissues was significantly higher in the death cases. Conclusions The expression of LN and its receptor (LN -R) is of great value in the malignant biological behavior of lung cancer and is a useful indicator of clinical treatment and prognosis