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应用肺阻抗血流图测定肺血管收缩反应的方法,研究44名健康男性肺血管对缺氧有收缩反应性的自愿者,由急性吸烟引起的缺氧性肺血管收缩反应性的变化,并探讨前列腺素和白三烯在其中的作用。结果:急性吸烟(15分钟内吸完香烟3支)使缺氧性肺血管收缩反应明显增强,服环氧合酶抑制剂(消炎痛,25毫克日3次,共4天)或脂氧合酶抑制剂(乙胺嗪,200毫克日3次,共3天)均可使由急性吸烟所致的肺血管反应增强显著减弱。前列腺素和白三烯在急性吸烟引起人的缺氧性肺血管反应性的增强中起介导作用。
To investigate the changes of pulmonary vasoconstriction response in pulmonary arterial blood flow diagrams and to investigate the changes of hypoxic pulmonary vasoconstriction reactivity in 44 healthy volunteers with hypoxic pulmonary vasoconstriction induced by acute smoking Prostaglandins and leukotrienes in which the role. RESULTS: Acute smoking (3 cigarettes smoked in 15 minutes) markedly attenuated hypoxic pulmonary vasoconstriction. The combination of cyclooxygenase inhibitors (indomethacin, 25 mg three times a day for 4 days) or lipoxygenase Enzyme inhibitors (diethylcarbamazine, 200 mg three times a day for 3 days) all significantly attenuated pulmonary vascular responses to acute smoking. Prostaglandins and leukotrienes play a mediating role in the enhancement of hypoxic pulmonary vascular reactivity induced by acute smoking in humans.