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目的探讨英夫利西单抗与甲氨蝶呤合用治疗类风湿关节炎的疗效和安全性。方法 32例类风湿关节炎患者均采用英夫利西单抗与甲氨蝶呤合用方式治疗,比较治疗前后的实验室指标以及临床症状。结果治疗后患者的各项指标均出现明显改善,风湿因子改善更为明显(P<0.01)。所有患者均未出现过敏性休克以及严重的不良反应,仅在输液中出现3例轻微、易消除的不良反应症患者。结论英夫利西单抗与甲氨蝶呤合用治疗类风湿关节炎,疗效显著,安全可靠,值得在临床推广应用。
Objective To investigate the efficacy and safety of the combination of infliximab and methotrexate in the treatment of rheumatoid arthritis. Methods 32 patients with rheumatoid arthritis were treated with infliximab combined with methotrexate, before and after treatment of laboratory indicators and clinical symptoms. Results After treatment, the indicators of patients showed a significant improvement, and the improvement of rheumatoid factor was more obvious (P <0.01). All patients did not have anaphylactic shock and serious adverse reactions, only in the infusion of 3 cases of mild, easy to eliminate adverse reactions in patients. Conclusion Infliximab combined with methotrexate treatment of rheumatoid arthritis, significant effect, safe and reliable, it is worth in the clinical application.