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目的：观察亚砷酸对复发的急性早幼粒细胞白血病的疗效。方法：复发的急性早幼粒细胞白血病２５例（男性１５例，女性１０例；年龄３４ａ±ｓ１２ａ）以亚砷酸１０ｍｇ／ｄ＋５％葡萄糖注射液５００ｍＬ静脉滴注，２８～５６ｄ为一个疗程。治疗过程中每周或至评价疗程时进行骨髓检查，每周至少２次血常规检查，并监测凝血纤溶指标和肝、肾功能等。结果：亚砷酸治疗２５例复发急性早幼粒细胞白血病，２４例达完全缓解，１例未缓解，缓解率９６％。对２４例完全缓解者随访，结果８例复发，复发率３３％，复发者经亚砷酸再次治疗，其中４例再次缓解，４例死亡。治疗中未出现严重不良反应。结论：亚砷酸是治疗对维Ａ酸耐药的复发急性早幼粒细胞白血病的有效药物，并相对比较安全
Objective: To observe the effect of arsenious acid on recurrent acute promyelocytic leukemia. Methods: 25 cases of recurrent acute promyelocytic leukemia (15 males and 10 females; age 34a ± s12a) were intravenously dripped with 500 mL of arsenious acid 10 mg / d and 5% glucose injection for 28 to 56 days. During the course of treatment or to evaluate the course of each bone marrow examination, at least 2 times a week, blood tests, and monitoring of coagulation and fibrinolysis and liver and kidney function. Results: Arsenite treatment of 25 cases of recurrent acute promyelocytic leukemia, 24 cases of complete remission, 1 case did not ease, the remission rate of 96%. Follow-up was performed on 24 patients with complete remission, and 8 patients relapsed with a recurrence rate of 33%. Recurrences were re-treated with arsenite. Among them, 4 were re-relieved and 4 died. No serious side effects occurred during the treatment. CONCLUSIONS: Arsenite is an effective drug for the treatment of vitamin A-resistant recurrent acute promyelocytic leukemia and is relatively safe