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头孢氨苄制剂(片剂、胶囊剂)的含量测定,中国药典90年版和95年版皆采用碱水解后的碘量法,操作步骤较多,不但费时,结果的重现性也较差,尤其缓冲液的配制方法对测定结果的影响最大。在实验中还发现,头孢氨苄在260nm左右有一个很好的紫外吸收峰,可以利用该吸收峰进行含量测定,经实验测定结果满意,现将实验情况报告如下。 一、药品与仪器 所用试剂皆为AR级。 头孢氨苄化学对照品(0408—P506
Cefalexin preparations (tablets, capsules) content determination, the Chinese Pharmacopoeia 90 years edition and the 95th edition are using alkali hydrolysis after iodometric method, more steps, not only time-consuming, the results are poor reproducibility, especially in the buffer The preparation method of liquid has the greatest influence on the determination result. In the experiment also found that cefalexin around 260nm has a good UV absorption peak, the absorption peak can be used to determine the content, the experimental results were satisfactory, the experimental report is as follows. First, the reagents used in medicine and equipment are AR grade. Cephalexin chemical reference (0408-P506