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目的探讨免疫细胞化学检查在脑膜癌病(MC)诊断中的作用。方法对13例MC患者的脑脊液标本21份分别进行常规脑脊液细胞学和免疫细胞化学检查,比较两种检查方法的阳性率。结果首次脑脊液检查阳性者常规脑脊液细胞学4例,而抗癌胚抗原(CEA)和抗上皮膜抗原(EMA)免疫细胞化学均为10例;总阳性率常规脑脊液细胞学为42.86%(9/21),抗CEA免疫细胞化学为80.95%(17/21),抗EMA免疫细胞化学为85.71%(18/21)。结论免疫细胞化学的敏感性高于常规脑脊液细胞学,可提高MC患者的早期确诊率。
Objective To investigate the role of immunocytochemistry in the diagnosis of meningeal carcinomatosis (MC). Methods Cerebrospinal fluid samples of 13 patients with MC were respectively subjected to routine cerebrospinal fluid cytology and immunocytochemistry. The positive rates of the two methods were compared. Results In the first cerebrospinal fluid tests, 4 patients had normal cerebrospinal fluid cytology, and 10 patients had anti-carcinoembryonic antigen (CEA) and anti-epithelial membrane antigen (EMA) immunocytochemistry. The total positive rate of routine cerebrospinal fluid cytology was 42.86% 21), anti-CEA immunocytochemistry was 80.95% (17/21) and anti-EMA immunocytochemistry was 85.71% (18/21). Conclusions Immunocytochemistry is more sensitive than conventional cerebrospinal fluid cytology and can improve the early diagnosis of MC.