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目的:观察生大黄治疗急性重症胰腺炎的临床疗效。方法:将70例急性重症胰腺炎患者随机分为2组,各35例。对照组给予常规急性重症胰腺炎治疗;研究组在对照组治疗基础上给予生大黄治疗。治疗1周。结果:总有效率研究组94.3%,对照组74.3%,2组比较,差异有统计学意义(P<0.05);研究组谷丙转氨酶水平、谷草转氨酶水平、总胆红素水平、白细胞介素-1以及白细胞介素-6水平均显著低于对照组,2组比较,差异均有统计学意义(P<0.05)。研究组首次排气时间、首次排便时间、恢复肠鸣音时间、血淀粉酶恢复时间、APACHEⅡ评分均显著优于对照组,2组比较,差异有统计学意义(P<0.05)。研究组并发症发生率8.6%、死亡率2.9%,对照组并发症发生率28.6%、死亡率14.3%。2组比较,差异有统计学意义(P<0.05)。结论:生大黄治疗急性重症胰腺炎临床疗效显著,具有安全性。
Objective: To observe the clinical efficacy of rhubarb in the treatment of acute severe pancreatitis. Methods: Seventy patients with severe acute pancreatitis were randomly divided into two groups (35 in each). The control group was given conventional acute severe pancreatitis; the study group was given rhubarb treatment based on the control group. Treatment for 1 week. Results: The total effective rate was 94.3% in the study group and 74.3% in the control group. There was significant difference between the two groups (P <0.05). The levels of alanine aminotransferase, aspartate aminotransferase, total bilirubin, interleukin -1 and IL-6 levels were significantly lower than the control group, the difference between the two groups was statistically significant (P <0.05). The time of the first expelling, the time of first defecation, the time of recovery of bowel sounds, the recovery time of serum amylase and the score of APACHEⅡ in the study group were significantly better than those in the control group. There was significant difference between the two groups (P <0.05). The incidence of complication in the study group was 8.6% and the mortality rate was 2.9%. The complication rate in the control group was 28.6% and the mortality rate was 14.3%. The difference between the two groups was statistically significant (P <0.05). Conclusion: The clinical efficacy of rhubarb in the treatment of acute severe pancreatitis is significant and safe.