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目的探讨经纤维支气管镜给药治疗支气管内膜结核(EBTB)的疗效。方法将68例支气管内膜结核患者随机分为治疗组及对照组各34例,对照组进行全身抗痨治疗,治疗组在此基础上进行纤支镜局部给药治疗,治疗后2个月两组检查结果比较。结果治疗组和对照组痰液结核菌检查有效转阴分别为25例(83.3%),12例(41.4%);治疗组和对照组临床表现有效好转分别为30例(88.2%),14例(41.2%),治疗组和对照组纤支镜检查明显好转分别为29例(85.3%),13例(38.2%),治疗组和对照组X线检查明显好转分别为27例(84.4%),12例(41.4%),治疗组在痰菌阴转,临床表现,纤支镜检查和X线检查疗效方面均优于对照组,差异均有统计学意义(P均<0.01)。结论在全身抗结核治疗基础上加纤维支气管镜下局部灌注抗痨药物治疗支气管内膜结核的临床疗效较单纯全身抗痨治疗好。
Objective To investigate the therapeutic effect of bronchofibroscope on bronchial endometrial tuberculosis (EBTB). Methods Sixty-eight patients with endobronchial tuberculosis were randomly divided into treatment group and control group, with 34 cases in each group. The control group was treated with systemic anti-tuberculosis therapy. The treatment group was treated with local bronchofiberscopy. Two months after treatment, Group test results comparison. Results In the treatment group and the control group, 25 cases (83.3%) and 12 cases (41.4%) of sputum TB were negative respectively. The effective improvement of the clinical manifestations in the treatment group and the control group were 30 cases (88.2%) and 14 cases (41.2%). In the treatment group and the control group, the bronchofibroscopy was significantly improved in 29 cases (85.3%) and 13 cases (38.2%), respectively. The improvement of X-ray examination in the treatment group and the control group was significantly improved , 12 cases (41.4%). The treatment group was better than the control group in sputum negative conversion, clinical manifestations, bronchoscopy and X-ray examination. The differences were statistically significant (all P <0.01). Conclusions The systemic curative effect of systemic anti-TB therapy plus bronchoscopic local anti-tuberculosis drugs on bronchial intima tuberculosis is better than systemic anti-tuberculosis therapy.