给大鼠灌胃联苯双酯后,用TLC法分离尿中代谢产物。发现尿中的主要代谢物为葡萄糖醛酸结合物,将此结合物水解后,用TLC法分离到一种极性较葡萄糖醛酸结合物为弱的代谢物,经光谱分析测定其结构为4-羟基-4′-甲氧基-5,6,5′,6′-二次甲二氧基-2,2′-二甲氧羰基联苯(简称4-去甲联苯双酯)。此外还证实,大鼠灌胃后在肝、肾组织中均以葡萄糖醛酸结合物为主,仪有少量非结合形代谢物和原形药物。 After gavage to rats, the metabolites in the urine were separated by TLC. Found that the urine of the main metabolite glucuronic acid conjugate, the conjugate hydrolyzed after the TLC method was separated to a polar glucuronic acid conjugate was weaker metabolites, the structure of the spectroscopic analysis of 4 Hydroxy-4’-methoxy-5,6,5 ’, 6’-dimethoxy-2,2’-dimethoxycarbonylbiphenyl (abbreviation: 4-norbiphenyl). In addition, it was also confirmed that glucuronic acid conjugates were mainly present in the liver and kidney tissues after gavage in rats, with a small amount of non-binding metabolites and prototype drugs.