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目的探讨幼年型甲状腺功能减退症并发性发育异常的病理机制。方法回顾分析近年来诊断的2例严重的幼年型甲状腺功能减退症并性发育异常临床资料及相关文献。结果甲状腺功能减退症并性发育异常有其独特临床表现和病理机制。结论高水平的TSH直接与FSH受体相互作用可能是其性发育异常的病理机制。
Objective To investigate the pathological mechanism of congenital dysplasia of juvenile hypothyroidism. Methods The clinical data and related literatures of 2 cases of severe hypothyroidism with sexual dysplasia diagnosed in recent years were retrospectively analyzed. Results Hypothyroidism and sexual dysplasia have their own unique clinical manifestations and pathological mechanisms. Conclusion The high level of TSH directly interacting with FSH receptors may be the pathological mechanism of its sexual dysplasia.