颅缝过早闭合(Craniosynostosis)的定义是颅缝过早地闭锁,致使颅骨形状异常(狭颅症)。这种异常可有下列3种形式:单纯异常(非综合征的);形态学缺陷的一部分(综合征性的);继发于其它疾病或中枢神经系统的畸型。出生活婴颅缝过早闭合的确实发生率是不明的。就作者所知,仅有一个关于新生儿颅缝过早闭合发生率总的估计的报告。做为确定先天性畸型发生率的前瞻性研究的一部分,在作者经历的新生儿中,作者记录了单纯的(非综合征的)颅 Craniosynostosis is defined as a premature locking of the craniosynostosis resulting in an abnormal skull shape (stenosis). This anomaly may have the following three forms: simple abnormal (non-syndromic); part of morphological defects (syndromic); secondary to other diseases or central nervous system abnormalities. The exact incidence of premature closing of cranial seams of living children is unknown. To the author’s knowledge, there is only one report on the overall estimate of the incidence of neonatal cranial suture premature closure. As part of a prospective study to determine the incidence of congenital malformations, the authors documented simple (non-syndromic) cranial