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目的:评价紫杉醇(Taxol)联合顺铂、醛氢叶酸和氟尿嘧啶(TPF方案)治疗晚期胃癌疗效及安全性。方法:对44例胃癌患者采用TFP方案化疗:紫杉醇175mg/m~2,静脉滴注,第1天;DDP75mg/m~2+生理盐水1500～2000ml第2天腹腔内灌注,第2天;醛氢叶酸200mg/m~2,静脉滴注,第2～4天:5-Fu250mg/m~2,静脉推注,第2天,后1500mg/m~2,72h持续静脉滴注。21天为一周期,两个周期后评定疗效。结果:44例均可评价疗效,完全缓解(CR) 3例,部分缓解(PR)23例,临床获益率(CR+PR+NC)为86.4%;进展(PD)6例,中位肿瘤进展期7.2个月,中位生存期9.8个月。不良反应主要表现为白细胞减少和恶心呕吐等胃肠道反应及脱发。结论:紫杉醇联合顺铂、醛氢叶酸和氟尿嘧啶是治疗晚期胃癌患者较好的化疗方案,临床缓解率较高,明显减轻患者痛苦,提高生活质量,毒副反应可耐受,可以作为初治或复发的晚期胃癌二线治疗方案。
Objective: To evaluate the efficacy and safety of paclitaxel (Taxol) combined with cisplatin, leucovorin, and fluorouracil (TPF) in the treatment of advanced gastric cancer. Methods: Forty-four patients with gastric cancer were treated with TFP regimen: paclitaxel 175mg/m~2 intravenous drip on the first day; DDP 75mg/m~2+ saline 1500~2000ml on the second day intraperitoneal perfusion on the second day; aldehyde Hydrogen folic acid 200mg/m~2, intravenous drip, 2nd to 4th day: 5-Fu 250mg/m~2, intravenous injection, on the 2nd day, after 1500mg/m~2,72h continuous intravenous drip. 21 days is a cycle, and the efficacy is evaluated after two cycles. RESULTS: The efficacy was evaluated in 44 cases, with complete remission (CR) in 3 cases, partial remission (PR) in 23 cases, clinical benefit rate (CR+PR+NC) of 86.4%; progression (PD) in 6 cases, median tumor The progression period is 7.2 months and the median survival period is 9.8 months. Adverse reactions mainly manifested in leukopenia and nausea and vomiting and other gastrointestinal reactions and hair loss. Conclusion: Paclitaxel combined with cisplatin, leucovorin and fluorouracil is a good chemotherapy regimen for patients with advanced gastric cancer. The clinical remission rate is high. It can significantly reduce the suffering of patients, improve the quality of life, toxic and side effects can be tolerated, and can be used as initial treatment or Recurrent second-line treatment of advanced gastric cancer.