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活性蛋白C(activated protein C,APC)抵抗是迄今所知促进静脉血栓形成最常见的遗传因素,约占未经选择的连续深静脉血栓病人的20％,健康人群的3％～7％。APC抵抗静脉血栓危险度增加2.7倍～7倍。部分活性促凝血酶原激酶时间(aPTT)延长反映了APC抵抗。脑静脉血栓(CVT)非常罕见,20％～35％的病例原因不明,作者用病例对照研究探讨凝血因子V基因突变与CVT的关系。 1990年～1996年巴黎圣·安妮医院共收治CVT23例,19例同意参加本研究,另57名年龄配对的健康
Activated protein C (APC) resistance is by far the most common genetic factor promoting venous thrombosis, accounting for about 20% of patients with unselected continuous deep venous thrombosis and 3% to 7% of healthy people. APC resistance to venous thrombosis increased 2.7 times to 7 times. Part of the prolonged active thromboplastin time (aPTT) reflects APC resistance. Cerebral venous thrombosis (CVT) is very rare, 20% ~ 35% of the cases for unknown reasons, the authors use a case-control study of coagulation factor V gene mutations and CVT relationship. From 1990 to 1996, St. Anne’s Hospital in Paris treated 23 patients with CVT, 19 patients agreed to participate in this study, and another 57 age-matched healthy