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目前已公认Barrett食管(BE)演变为腺癌要经过上皮化生-异型增生-腺癌3个阶段。食管腺癌的发生、发展不仅存在细胞的增殖和分化的异常,同时也存在细胞凋亡异常。目前已发现的在BE进展为食管腺癌过程中可能有重要作用的细胞凋亡调节因子主要有:(1)fas/fas L;(2)TRAIL(肿瘤坏死因?
Barrett’s esophagus (BE) has now been recognized as adenocarcinoma to go through epithelial metaplasia - dysplasia - adenocarcinoma three stages. The occurrence and development of esophageal adenocarcinoma not only exist abnormalities of cell proliferation and differentiation, but also have abnormal apoptosis. So far, it has been found that there are mainly regulatory factors that may play an important role in the progression of BE to esophageal adenocarcinoma: (1) fas / fas L; (2) TRAIL (tumor necrosis factor?