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前列腺素(Prostaglandins,简称PGs)是一族由20个碳原子的不饱和脂肪酸组成的生物活性物质,它们参与对子宫平滑肌的调控。本文就子宫内PGs的合成与释放,有关激素和钙离子对其合成与释放的影响,以及PGs对子宫肌的作用及其机理作一简要综述。一、子宫内PGs的合成与释放子宫可将花生四烯酸经环加氧酶途径合成多种PGs,亦可经5-脂加氧酶途径合成白三烯类(Leukotrienes,简称LTs)以及经12-脂加氧酶途径合成12-HETE等。在子宫内呈现重要生物活性的PGs主要有PGE_2、PGF_(2α)、PGI_2及TXA_2/TXB_2等。子宫合成与释放PGs与性周期有一定关联。Thaler等报道了大鼠离体子宫在动情周期中
Prostaglandins (PGs) are a group of biologically active substances composed of unsaturated fatty acids of 20 carbon atoms, which are involved in the regulation of uterine smooth muscle. In this paper, intrauterine synthesis and release of PGs, hormones and calcium on its synthesis and release, as well as PGs on the role of uterine muscle and its mechanism for a brief review. First, intrauterine synthesis and release of PGs uterus can arachidonic acid via the cyclooxygenase pathway synthesis of a variety of PGs, but also through the 5-lipoxygenase pathway synthesis of leukotrienes (Leukotrienes, referred to as LTs) and the 12-lipoxygenase pathway synthesis 12-HETE and so on. PGs that show important biological activity in the uterus mainly include PGE_2, PGF_ (2α), PGI_2 and TXA_2 / TXB_2. Uterine synthesis and release of PGs and sexual cycles have a certain relationship. Thaler et al reported the rat uterus in the estrous cycle