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报告２例结缔组织病患者在应用皮质类固醇治疗过程中出现类固醇肌病。其主要临床表现为盆带肌无力。肌活检病理组化特点为选择性Ⅱ型纤维萎缩伴Ⅰ型纤维内脂质增加。电镜观察发现肌原纤维萎缩，其间有大量变性线粒体、糖原及脂滴聚积。本文还结合文献对类固醇肌病的诊断、鉴别诊断及处理措施进行了讨论。
Two patients with connective tissue disease were reported to have steroid myopathy during treatment with corticosteroids. The main clinical manifestations of pelvic muscle weakness. Pathological features of muscle biopsy is characterized by selective type Ⅱ fibrosis with type Ⅰ fiber lipid increased. Electron microscopy showed myofibrillar atrophy, during which a large number of degeneration of mitochondria, glycogen and lipid droplets accumulation. This article also combined with the literature on steroid myopathy diagnosis, differential diagnosis and treatment measures were discussed.