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目的:探讨大剂量奥美拉唑治疗急性胃炎导致上消化道出血的效果。方法:选取我院2006年6月至2011年5月收治的80例胃炎致上消化道出血的患者,将其随机平均分为两组,一组为对照组,一组为观察组,对照组采用常规剂量的奥美拉唑进行静脉滴注,每隔12小时滴注一次,每次用量为四十毫克;观察组采用大剂量奥美拉唑静脉滴注,第一次滴注四十毫克,然后每小时以八毫克的量持续滴注。记录两组患者的止血时间、第二次出血时间及总输血毫升数。结果:观察组患者的平均输血量为(398.2±127.3)毫升,对照组患者的平均输血量为(540.1±232.4)毫升。观察组40例患者,有效38例,占95.0%,对照组40例患者,有效30例,占75.0%,两组总有效率具有显著性差异(P<0.05)。结论:应用大剂量奥美拉唑治疗胃炎导致的上消化道出血,具有明显的临床效果,有利于减少治疗中的输血量。
Objective: To investigate the effect of high-dose omeprazole on acute gastritis caused by upper gastrointestinal bleeding. Methods: Eighty patients with gastritis caused by upper gastrointestinal bleeding who were treated in our hospital from June 2006 to May 2011 were randomly divided into two groups, one was control group, the other was control group The conventional dose of omeprazole for intravenous drip, drip once every 12 hours, each dose of 40 mg; the observation group using high-dose omeprazole intravenous drip, the first infusion of 40 mg , And then continue dripped with eight milligrams per hour. Record two groups of patients bleeding time, the second bleeding time and the total number of blood transfusions. RESULTS: The mean blood transfusion in the observation group was (398.2 ± 127.3) mL and in the control group was 540.1 ± 232.4 mL. The observation group of 40 patients, effective in 38 cases, accounting for 95.0%, 40 patients in the control group, effective in 30 cases, accounting for 75.0%, the total effective rate was significantly different (P <0.05). Conclusion: The application of high-dose omeprazole in the treatment of upper gastrointestinal bleeding caused by gastritis has obvious clinical effect and is beneficial to reduce the volume of blood transfusion during treatment.