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目前用于治疗日本血吸虫病的最有效药物是吡喹酮和羟氨喹,但新近报道对此药物的抗性血吸虫可能正在产生,因而要求发展新型的药物。蒿甲醚(Artemether)是一种抗疟药青篙素的衍生物,据报道在体内对曼氏血吸虫有杀伤作用。在中国曾将它用于小鼠和狗体内日本血吸虫感染的治疗试验,结果表明有作用。可见蒿甲醚是一种具有抗疟和抗血吸虫潜在作用的药物。本研究对此药物对小鼠体内日本血吸虫日本株的作用效果进行评价。
The most potent drugs currently used to treat schistosomiasis japonica are praziquantel and hydroxyquinate, but recently the resistance to this drug, schistosomiasis, may be under development and calls for the development of new drugs. Artemether, a derivative of the anti-malarial luteolin, has been reported to kill Schistosoma mansoni in the body. It has been used in China for the treatment of Schistosoma japonicum infection in mice and dogs, and results have shown to be useful. It can be seen that artemether is a potential anti-malarial and anti-schistosome drug. In this study, the effect of this drug on Japanese Schistosoma japonicum in mice was evaluated.