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目的:探讨益经汤对去势大鼠血清性激素及子宫组织形态的影响。方法:将50只12周龄SD未孕雌性大鼠随机分为假手术组、模型组、益经汤高剂量组、益经汤低剂量组、西药对照组。给药6周后化学发光免疫法测定大鼠血清E2、FSH含量及观察子宫组织形态。结果:与模型组相比,益经汤高剂量组、益经汤低剂量组、西药组均能提高血清E2的含量(P<0.01),降低血清FSH的含量(P<0.01);子宫组织形态显示益经汤高剂量和西药补佳乐均能使子宫内膜上皮增生,使间质致密、血管丰富。结论:益经汤对去势大鼠生殖内分泌有显著的保护功能,机制可能是通过提高雌激素的含量,降低卵泡刺激素的分泌。益经汤高剂量和西药补佳乐效果相当。
Objective: To investigate the effects of Yijing Decoction on serum sex hormones and uterine morphology in ovariectomized rats. Methods: Fifty non-pregnant SD rats of 12 weeks old were randomly divided into sham operation group, model group, Yijing Decoction high dose group, Yijing Decoction low dose group and western medicine control group. Six weeks after the administration, chemiluminescence immunoassay was used to determine the serum levels of E2 and FSH and to observe the morphology of the uterus. Results: Compared with the model group, the Yijing Decoction high dose group, Yijing Decoction low dose group and western medicine group can increase the level of serum E2 (P <0.01) and the level of serum FSH (P <0.01) Morphology Yiyitang high dose and Western medicine to make music can make the endometrial epithelial hyperplasia, the interstitial dense, rich in blood vessels. Conclusion: Yijing Decoction has significant protective function on reproductive endocrine in ovariectomized rats. The mechanism may be that the estrogen content is reduced and the secretion of follicle stimulating hormone is reduced. Yi Jing Tang high doses and Western Jianeng effect quite.