白血病干细胞(LSC)的发现使研究者能够更深入地阐释白血病的发病、复发、耐药等机制,为白血病的靶向治疗开拓了新的途径。LSC与正常造血干细胞(HSC)有许多相似之处,如都具有自我更新能力和多向分化潜能,同时又具有自身独特的生物学性质。它具有某些特殊的细胞表面标志;有其自身的细胞周期特点。本文阐述了核因子(NF)-κB、Flt3等分子在LSC中的分子调控机制及近年来LSC靶向治疗方面的研究进展。 The discovery of leukemic stem cells (LSC) enables researchers to more in-depth elucidation of pathogenesis, relapse, drug resistance and other mechanisms of leukemia, opened up new avenues for the targeted therapy of leukemia. There are many similarities between LSCs and normal hematopoietic stem cells (HSCs), such as their self-renewal ability and multi-directional differentiation potential, as well as their own unique biological properties. It has some special cell surface markers; it has its own cell cycle characteristics. This article describes the molecular regulation mechanisms of nuclear factor (NF) -κB, Flt3 and other molecules in LSC and the progress of LSC targeted therapy in recent years.