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细胞间通讯是发育中的重要事件。大量的研究表明,Hedgehog信号通路对于动物的正常胚胎发育和器官形成具有重要作用。其调节异常可导致严重的疾病,包括各种发育缺陷和癌症等。本文就Hedgehog信号通路的组成及其与乳腺发育和乳腺癌发生的关系研究进展进行综述。1Hedgehog信号通路
Cell-cell communication is an important developmental event. Numerous studies have shown that the Hedgehog signaling pathway plays an important role in normal embryonic development and organ formation in animals. The abnormal regulation can lead to serious diseases, including various developmental defects and cancers. This review summarizes the composition of Hedgehog signaling pathway and its relationship with breast development and breast cancer. 1Hedgehog signaling pathway