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目的:探讨PCOS妇女促排卵治疗后着床窗口期子宫内膜MIF和VEGF的表达。方法:10例PCOS患者内分泌紊乱纠正、自然排卵或促排卵治疗后(PCOS组)和11例其他原因不孕妇女自然周期(对照组)着床窗口期取子宫内膜进行MIF和VEGF免疫组化染色,并进行统计学分析。结果:PCOS组着床窗口期子宫内膜MIF和VEGF较对照组低表达,MIF与VEGF的表达呈显著正相关。结论:PCOS患者着床窗口期子宫内膜中MIF、VEGF的低表达可能影响着床过程的多个环节,是造成PCOS患者内分泌紊乱纠正后仍出现妊娠率低、流产率高的原因之一。
Objective: To investigate the expression of MIF and VEGF in endometrium at implantation window after ovulation induction in PCOS women. Methods: 10 cases of PCOS patients with endocrine disorders correction, spontaneous ovulation or ovulation induction treatment (PCOS group) and 11 cases of other causes of infertility women natural period (control group) implantation window endometrium for MIF and VEGF immunohistochemistry Dyeing, and statistical analysis. Results: The expression of MIF and VEGF in endometrium of PCOS group was lower than that of control group in implantation window, and there was a significant positive correlation between MIF and VEGF expression. CONCLUSION: Low expression of MIF and VEGF in implantation window of endometrial PCOS patients may affect many aspects of the implantation process. It is one of the reasons for the low pregnancy rate and high miscarriage rate after the correction of endocrine disorders in PCOS patients.