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目的观察奥沙利铂辅助化疗方案治疗晚期结肠癌的疗效。方法将晚期结肠癌患者76例按照随机数字法分为观察组和对照组各38例。对照组给予常规化疗,观察组患者采用奥沙利铂联合常规化疗治疗。比较2组患者的治疗效果。结果 2组患者治疗效果比较差异无统计学意义(P>0.05)。随访2年,观察组患者存活率高于对照组,病死率和并发症发生率低于对照组,差异均有统计学意义(P<0.05)。结论常规化疗和奥沙利铂辅助化疗方案治疗晚期结肠癌效果均显著,但奥沙利铂辅助化疗方案的远期疗效更好,并发症较少,值得临床推广。
Objective To observe the efficacy of oxaliplatin adjuvant chemotherapy in the treatment of advanced colon cancer. Methods 76 cases of advanced colon cancer patients were divided into observation group and control group according to random number method in 38 cases. Control group given conventional chemotherapy, observation group patients with oxaliplatin combined with conventional chemotherapy. Compare the treatment effect of 2 groups of patients. Results There was no significant difference in the treatment effect between the two groups (P> 0.05). The follow-up of 2 years, the observation group patients survival rate was higher than the control group, mortality and complications were lower than the control group, the difference was statistically significant (P <0.05). Conclusion Both conventional chemotherapy and oxaliplatin adjuvant chemotherapy are effective in treating advanced colon cancer. However, the long-term curative effect of oxaliplatin adjuvant chemotherapy is better and the complication is less, which is worthy of clinical promotion.