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目的 研究近年系统性红斑狼疮 (SLE)患者发生细菌与真菌感染的临床特点。方法 选择 1990年 1月至 1998年 5月确诊为SLE并发细菌和真菌感染的病例 96例 ,统计分析有关资料。结果 96例SLE患者共发生 15 1例次感染 ,其中医院感染占 48 3% ;革兰氏阴性 (G-)杆菌和革兰氏阳性 (G+ )球菌感染分别占 40 4%和 30 5 % ,真菌占 18 5 % ,其他细菌占 10 6 % ;2 7例次(17 9% )感染由细胞壁缺陷型 (L型 )细菌引起。感染发生后 5 0 %以上的患者无明显感染中毒表现。结论 SLE患者感染的临床表现与一般感染有所不同 ;医院感染发生率较高 ;G-杆菌是其最常见病原菌。及时采集有关标本作L型细菌培养可减少对感染的误诊、漏诊
Objective To study the clinical features of bacterial and fungal infections in patients with systemic lupus erythematosus (SLE) in recent years. Methods A total of 96 cases of bacterial and fungal infections diagnosed as SLE from January 1990 to May 1998 were selected and statistically analyzed. Results A total of 151 infections were found in 96 patients with SLE, of which 48.3% were hospital infection. 40.4% and 30.5% were Gram-negative bacteria and Gram-positive bacteria respectively, Fungi accounted for 18.5%, other bacteria accounted for 106%; 27 cases (17.9%) infection caused by cell wall defects (L type) bacteria. After infection more than 50% of patients without obvious infection poisoning performance. Conclusions The clinical manifestations of SLE infection are different from those of general infection. The incidence of nosocomial infection is high. G-Bacillus is the most common pathogen. Timely collection of relevant specimens for L-type bacterial culture can reduce the misdiagnosis of infection, missed diagnosis