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目的 了解广西地区狂犬病高发年代后的不同类型疫区中家犬自然感染状况和犬伤者狂犬病疫苗免疫后抗体水平 ,为防制狂犬病提供科学依据。方法 对广西狂犬病不同疫区进行病原学和免疫血清学的监测比较。结果 健康犬脑狂犬病毒带毒率 ,持续流行疫区 (11.11% )高于休止期老疫区 (5 .0 % )的 1倍以上。对于狂犬疫苗全程免疫后 (45天 )血清抗体阳性率 ,休止期老疫区(92 .3% )高于持续流行疫区 (75 .0 % )和休止期新疫区 (70 .0 %～ 38.5 % )。这些差异可以反映出一定的地区特点。结论 不同类型疫区狂犬病免疫和预防失败可能是疫苗株和地方株之间缺乏交叉反应所致。
Objective To understand the natural infection status of domestic dogs and the antibody levels of rabies vaccine against rabies in Guangxi Zhuang Autonomous Region after the high incidence of rabies in Guangxi in order to provide a scientific basis for the prevention of rabies. Methods To compare the etiology and immunological serology of rabies in different epidemic areas of Guangxi. Results The prevalence rate of rabies virus in healthy dogs was higher than that of persistent epidemic areas (11.11%) than that of the resting epidemic areas (5.0%). Serum antibody positive rate after rabies vaccine immunization (45 days) was higher than that in persistent epidemic area (75.0%) and quiescent new area (70.0% ~ 38.5%). These differences can reflect certain regional characteristics. Conclusion The rabies immunization and prevention failure in different types of epidemic areas may be caused by the lack of cross-reaction between vaccine strains and local strains.